Organocatalysis in C=C Formation : A Stereoselective and Practical Synthesis of (E)-α,β-Unsaturated Ketones from Aldehydes

The conditions used in the Knoevenagel reaction to prepare conjugated esters under amino acid organocatalysis can be applied also for the synthesis of ,β unsaturated ketones. β-Keto acids are prepared by hydrogenolysis of the corresponding benzyl ester and react easily with aldehydes to give the ,β-unsaturated ketones without formation of high molecular weight byproducts.

DOI: 10.1002/ejoc.201001182


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