Organocatalysis in C=C Formation : A Stereoselective and Practical Synthesis of (E)-α,β-Unsaturated Ketones from Aldehydes

The conditions used in the Knoevenagel reaction to prepare conjugated esters under amino acid organocatalysis can be applied also for the synthesis of ,β unsaturated ketones. β-Keto acids are prepared by hydrogenolysis of the corresponding benzyl ester and react easily with aldehydes to give the ,β-unsaturated ketones without formation of high molecular weight byproducts.

http://onlinelibrary.wiley.com/store/10.1002/ejoc.201001182/asset/supinfo/ejoc_201001182_sm_miscellaneous_information.pdf?v=1&s=1518d2094fa3a9d8f3cdf9d317bf0b6bf69b6790


http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201001182/abstract

DOI: 10.1002/ejoc.201001182


ORGANIC PROCESS DEVELOPMENT

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