DR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues,
Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India.
Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now Rpg lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 25 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.
He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide .
He suffered a paralytic stroke in dec 2006 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, email@example.com
The conditions used in the Knoevenagel reaction to prepare conjugated esters under amino acid organocatalysis can be applied also for the synthesis of ,β unsaturated ketones. β-Keto acids are prepared by hydrogenolysis of the corresponding benzyl ester and react easily with aldehydes to give the ,β-unsaturated ketones without formation of high molecular weight byproducts.
The use of catalytic amounts of sodiumhydride as an efficient promoter for the dimerization of aromatic and even heteroaromatic aldehydes under standard laboratory conditions is reported. A range of substituted aromatic and heteroaromatic aldehydes was converted, and the corresponding esters were obtained in good to excellent yields even on a multigram scale.
A Novel Crystallization Methodology To Ensure Isolation of the Most Stable Crystal Form Aaron Cote, George Zhou and Mary Stanik Org. Process Res. Dev., 2009, 13 (6), pp 1276–1283
It is critical to consistently achieve the desired crystal form for an active pharmaceutical ingredient (API) because crystal form may affect the compound’s chemical stability, bioavailability, and pharmaceutical processing performance